The Spanish Stroke Genetics Consortium
The GeneStroke project is a consortium of research groups who share the same interest in elucidating the genetic markers implicated in stroke. It was established in 2008 and is open to groups from all over Spain. The consortium’s main goal is to create collaborations between stroke research groups who work in the fields of genetics or genomics, in order to obtain sufficient sample sizes to analyze variables with great power and accuracy and promote the sharing of ideas and data in the scientific community.
The GeneStroke consortium has a particular great interest in performing genome-wide association studies (GWAS), which methodology consists in screening about 95% of the human genome in an effort to identify associations of gene variants with observable traits or the presence or absence of a disease. GWAS involve generally scanning thousands to ten of thousands of samples for hundreds of thousands of SNPs. In contrast to candidate gene studies, GWAS allow a meticulous scan of the genome in an unbiased manner and thus have the potential to identify totally new susceptibility factors. They require the availability of efficient analytical tools and large sample sizes. Very few genome-wide association studies have been performed up to date in the genetics of stroke.
5th ESOC is near!
Next European Stroke Organization Congress (ESOC) will be on Milan, Italy (22-24th May 2019).
Last results from GODS project are published on Circulation Research journal: "PATJ Low Frequency Variants Are Associated With Worse Ischemic Stroke Functional Outcome".
February 22: GeneStroke membership meeting in Barcelona
The main topics discussed were the results obtained in the GODS project and the different results in epigenetics of stroke patients.