• Genetic variants in CETP increase risk of intracerebral hemorrhage.

Anderson CD, Falcone GJ, Phuah CL, Radmanesh F, Brouwers HB, Battey TW, Biffi A, Peloso GM, Liu DJ, Ayres AM, Goldstein JN, Viswanathan A, Greenberg SM, Selim M, Meschia JF, Brown DL, Worrall BB, Silliman SL, Tirschwell DL, Flaherty ML, Kraft P, Jagiella JM, Schmidt H, Hansen BM, Jimenez-Conde J, Giralt-Steinhauer E, Elosua R, Cuadrado-Godia E, Soriano C, van Nieuwenhuizen KM, Klijn CJ, Rannikmae K, Samarasekera N, Salman RA, Sudlow CL, Deary IJ, Morotti A, Pezzini A, Pera J, Urbanik A, Pichler A, Enzinger C, Norrving B, Montaner J, Fernandez-Cadenas I, Delgado P, Roquer J, Lindgren A, Slowik A, Schmidt R, Kidwell CS, Kittner SJ, Waddy SP, Langefeld CD, Abecasis G, Willer CJ, Kathiresan S, Woo D, Rosand J; Global Lipids Genetics Consortium and International Stroke Genetics Consortium. Ann Neurol. 2016 Nov;80(5):730-740

​

• Identification of additional risk loci for stroke and small vessel disease: a meta-analysis of genome-wide association studies.

Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium; Stroke Genetics Network (SiGN); International Stroke Genetics Consortium (ISGC). Lancet Neurol. 2016 Jun;15(7):695-707. doi: 10.1016/S1474-4422(16)00102-2​

​

• Ischemic stroke patients are biologically older than their chronological age.

Soriano-Tárraga C, Giralt-Steinhauer E, Mola-Caminal M, Vivanco-Hidalgo RM, Ois A, Rodríguez-Campello A, Cuadrado-Godia E, Sayols-Baixeras, Elosua R, Roquer J, Jiménez-Conde J. Aging (Albany NY). 2016 Aug 25;8(11):2655-2666.

​

• Whole exome sequencing analysis reveals TRPV3 as a risk factor for cardioembolic stroke.

Carrera C, Jiménez-Conde J, Derdak S, Rabionet K, Vives-Bauzá C, Soriano-Tárrega C, Giralt-Steinhauer E, Mola-Caminal M, Diaz-Navarro RM, Tur S, Muiño E, Gallego-Fabrega C, Beltran S, Roquer J, Ruiz A, Sotolongo-Grau O, Krupinski J, Lee JM, Cruchaga C, Delgado P, Malik R, Worrall BB, Seshadri S, Montaner J, Fernández-Cadenas I; Metastroke Consortium, ISGC Consortium and Genestroke Consortium. Thromb Haemost. 2016 Nov 30;116(6):1165-1171.

​

• Loci associated with ischaemic stroke and its subtypes (SiGN): a genome-wide association study.

NINDS Stroke Genetics Network (SiGN); International Stroke Genetics Consortium (ISGC). Lancet Neurol. 2016; 15:
174–84.

 

• Genome-wide meta-analysis of cerebral white matter hyperintensities in patients with stroke.

Traylor M, Zhang CR, Adib-Samii P, et al. International Stroke Genetics Consortium. Neurology. 2016 Jan 12;
86(2):146-53.

 

• Epigenome-Wide association study identifies TXNIP gene associated with Type 2 diabetes mellitus and sustained hyperglycemia.

Soriano-Tárraga C, Jiménez-Conde J, Giralt-Steinhauer E, Mola-Caminal M, Vivanco-Hidalgo RM, Ois A,
Rodríguez-Campello A, Cuadrado-Godia E, Sayols-Baixeras S, Elosua R, Roquer J; GENESTROKE Consortium.
Hum Mol Genet, 2015 Dec.

 

• DNA methylation levels are highly correlated between pooled samples and averaged values when analysed using the Infinium HumanMethylation450 BeadChip array.

Gallego-Fabrega C, Carrera C, Muiño E, Montaner J, Krupinski J, Fernandez-Cadenas I; Spanish Stroke Genetics Consortium. Clinical Epigenetics. 2015.

 

• An Inflammatory Polymorphisms Risk Scoring System for the Differentiation
  of Ischemic Stroke Subtypes.

Muiño E, Krupinski J, Carrera C, Gallego-Fabrega C, Montaner J, Fernández-Cadenas I. Mediators Inflamm.
2015.

 

• Common variation in COL4A1/COL4A2 is associated with sporadic cerebral small vessel disease.

Rannikmäe K, Davies G, Thomson PA, Bevan S, Devan WJ, Falcone GJ, Traylor M, Anderson CD, Battey TW, Radmanesh F, Deka R, Woo JG, Martin LJ, Jimenez-Conde J, Selim M, Brown DL, Silliman SL, Kidwell CS, Montaner J, Langefeld CD, Slowik A, Hansen BM, Lindgren AG, Meschia JF, Fornage M, Bis JC, Debette S, Ikram MA, Longstreth WT, Schmidt R, Zhang CR, Yang Q, Sharma P, Kittner SJ, Mitchell BD, Holliday EG, Levi CR, Attia J, Rothwell PM, Poole DL, Boncoraglio GB, Psaty BM, Malik R, Rost N, Worrall BB, Dichgans M, Van Agtmael T, Woo D, Markus HS, Seshadri S, Rosand J, Sudlow CL2; METASTROKE Consortium, the CHARGE WMH Group, the ISGC ICH GWAS Study Collaboration, the WMH in Ischemic Stroke GWAS Study Collaboration, and the International Stroke Genetics Consortium. Neurology. 2015 Mar 3.

 

 

• Recommendations From the International Stroke Genetics Consortium, Part 2. Biological Sample Collection and Storage.

Battey TW, Valant V, Kassis SB, Kourkoulis C, Lee C, Anderson CD, Falcone GJ, Jimenez-Conde J, Fernandez-Cadenas I, Pare G, Rundek T, James ML, Lemmens R, Lee TH, Tatlisumak T, Kittner SJ, Lindgren A, Mateen FJ, Berkowitz AL, Holliday EG, Majersik J, Maguire J, Sudlow C, Rosand J; International Stroke Genetics Consortium. Stroke. 2015 Jan.

 

 

• Recommendations From the International Stroke Genetics Consortium, Part 1. Standardized Phenotypic Data Collection.

Battey TW, Valant V, Kassis SB, Kourkoulis C, Lee C, Anderson CD, Falcone GJ, Jimenez-Conde J, Fernandez-Cadenas I, Pare G, Rundek T, James ML, Lemmens R, Lee TH, Tatlisumak T, Kittner SJ, Lindgren A, Mateen FJ, Berkowitz AL, Holliday EG, Majersik J, Maguire J, Sudlow C, Rosand J; International Stroke Genetics Consortium. Stroke. 2015 Jan.

 

 

• Pathogenic Ischemic Stroke Phenotypes in the NINDS-Stroke Genetics Network.

Ay H, Arsava EM, Andsberg G, Benner T, Brown RD Jr, Chapman SN, Cole JW, Delavaran H, Dichgans M, Engström G, Giralt-Steinhauer E, Grewal RP, Gwinn K, Jern C, Jimenez-Conde J, Jood K, Katsnelson M, Kissela B, Kittner SJ, Kleindorfer DO, Labovitz DL, Lanfranconi S, Lee JM, Lehm M, Lemmens R, Levi C, Li L, Lindgren A, Markus HS, McArdle PF, Melander O, Norrving B, Peddareddygari LR, Pedersén A, Pera J, Rannikmäe K, Rexrode KM, Rhodes D, Rich SS, Roquer J, Rosand J, Rothwell PM, Rundek T, Sacco RL, Schmidt R, Schürks M, Seiler S, Sharma P, Slowik A, Sudlow C, Thijs V, Woodfield R, Worrall BB, Meschia JF. Stroke. 2014 Dec.

 

 

• Agreement between TOAST and CCS ischemic stroke classification: The NINDS SiGN Study.

McArdle PF, Kittner SJ, Ay H, Brown RD Jr, Meschia JF, Rundek T, Wassertheil-Smoller S, Woo D, Andsberg G, Biffi A, Brenner DA, Cole JW, Corriveau R, de Bakker PI, Delavaran H, Dichgans M, Grewal RP, Gwinn K, Huq M, Jern C, Jimenez-Conde J, Jood K, Kaplan RC, Katschnig P, Katsnelson M, Labovitz DL,Lemmens R, Li L, Lindgren A, Markus HS, Peddareddygari LR, Pedersén A, Pera J, Redfors P, Roquer J, Rosand J, Rost NS, Rothwell PM, Sacco RL, Sharma P, Slowik A, Sudlow C, Thijs V, Tiedt S, Valenti R, Worrall BB; NINDS SiGN Study. Neurology. 2014 Oct 18.

 

 

• Global DNA methylation of ischemic stroke subtypes.

Soriano-Tárraga C, Jiménez-Conde J, Giralt-Steinhauer E, Mola M, Ois A, Rodríguez-Campello A, Cuadrado-Godia E, Fernández-Cadenas I, Carrera C, Montaner J, Elosua R, Roquer J. GeneStroke, “The Spanish Stroke Genetics Consortium”. PLoS One. 2014 Apr 30.

 

 

• Meta-analysis of genome-wide association studies identifies 1q22 as a susceptibility locus for intracerebral hemorrhage.

Woo D, Falcone GJ, Devan WJ, [...], Jiménez-Conde J, Giralt-Steinhauer E, Elosua R, Cuadrado-Godia E, Soriano C, Roquer J, Kraft P, Ayres AM, Schwab K, McCauley JL, Pera J, Urbanik A, Rost NS, Goldstein JN, Viswanathan A, Selim M, Brown DL, Silliman SL, Worrall BB, Meschia JF, Kidwell CS, Montaner J, Fernández-

Cadenas I, Delgado P, Malik R, Dichgans M, Greenberg SM, Rothwell PM, Lindgren A, Slowik A, Schmidt R, Langefeld CD, Rosand J. International Stroke Genetics Consortium. Am J Hum Genet. 2014 Apr 3.

 

 

• Drug resistance and secondary treatment of ischaemic stroke: The genetic component of the response to acetylsalicylic acid and clopidogrel.

Gallego-Fabrega C, Krupinski J, Fernandez-Cadenas I; en nombre de Genestroke Consortium, Consorcio Español para el Estudio Genético del Ictus. Neurologia. 2014 Mar 21.

 

 

• Stroke Genetics Network (SiGN) Study: Design and Rationale for a Genome-Wide Association Study of Ischemic Stroke Subtypes.

Meschia JF, Arnett DK, Ay H, Brown RD Jr, Benavente OR, Cole JW, de Bakker PI, Dichgans M, Doheny KF, Fornage M, Conde JJ, Rosand J, Woo D et al; on behalf of the NINDS SiGN Study. Stroke 2013 Sep 12.

 

 

• Exploring the genetic basis of stroke. Spanish stroke genetics consortium.

Giralt-Steinhauer E, Jiménez-Conde J, Soriano Tárraga C, Mola M, Rodríguez-Campello A, Cuadrado-Godia E, Ois A, Fernández-Cádenas I, Carrera C,Montaner J, Díaz Navarro RM, Vives-Bauzá C, Roquer J. Neurología 2013 June 4.

 

 

• Genes involved in hemorrhagic transformations that follow recombinant t-PA treatment in stroke patients.

Fernandez-Cadenas I, Rio-Espinola AD, Domingues-Montanari S, Montaner J et al. Pharmacogenomics. 2013 April.

 

 

• DNA Isolation Method is a Source of Global DNA Methylation Variability Measured with LUMA. Experimental analysis and a systematic review.

Carolina Soriano-Tárraga, Jordi Jiménez-Conde, Eva Giralt-Steinhauer, Ángel Ois, Ana Rodríguez-Campello, Elisa Cuadrado-Godia, Israel Fernández-Cadenas, Joan Montaner, Gavin Lucas, Roberto Elosua and Jaume Roquer. PLOS ONE. 2013 April 9.

 

 

• Aproximación al conocimiento de las bases genéticas del ictus. Consorcio Español de Genética del Ictus.

Eva Giralt-Steinhauer, Jordi Jiménez-Conde, Carolina Soriano-Tárraga, Marina Mola-Caminal, Ana Rodríguez-

Campello, Elisa Cuadrado-Godia, Ángel Ois, Israel Fernández-Cadenas, Caty Carrera, Joan Montaner, Rosa Maria Díaz Navarro, Cristòfol Vives-Bauzá and Jaume Roquer. Neurología (2013).

 

 

• Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE Collaboration): a meta-analysis of genome-wide association studies.

Traylor M, Farrall M, Holliday EG, Sudlow C, Hopewell JC, Cheng YC, Fornage M, Ikram MA, Malik R, Bevan S, Thorsteinsdottir U, Nalls MA, Longstreth W, Wiggins KL, Yadav S, Parati EA, Destefano AL, Worrall BB, Kittner SJ, Khan MS, Reiner AP, Helgadottir A, Achterberg S, Fernandez-Cadenas I, Abboud S, Schmidt R, Walters M, Chen WM, Ringelstein EB, O'Donnell M, Ho WK, Pera J, Lemmens R, Norrving B, Higgins P, Benn M, Sale M, Kuhlenbäumer G, Doney AS, Vicente AM, Delavaran H, Algra A, Davies G, Oliveira SA, Palmer CN, Deary I, Schmidt H, Pandolfo M, Montaner J, Carty C, de Bakker PI, Kostulas K, Ferro JM, van Zuydam NR, Valdimarsson E, Nordestgaard BG, Lindgren A, Thijs V, Slowik A, Saleheen D, Paré G, Berger K, Thorleifsson G; The Australian Stroke Genetics Collaborative, WTCCC2, et al.; on behalf of the International Stroke Genetics Consortium. Lancet Neurol. (2012)

 

 

• Burden of Risk Alleles for Hypertension Increases Risk of Intracerebral Hemorrhage.

Falcone GJ, Biffi A, Devan WJ, Jagiella JM, Schmidt H, Kissela B, Hansen BM, Jimenez-Conde J, Giralt-Steinhauer E, Elosua R, Cuadrado-Godia E, Soriano C, Ayres AM, Schwab K, Pera J, Urbanik A, Rost NS, Goldstein JN, Viswanathan A, Pichler A, Enzinger C, Norrving B, Tirschwell DL, Selim M, Brown DL, Silliman SL, Worrall BB, Meschia JF, Kidwell CS, Montaner J, Fernandez-Cadenas I, Delgado P, Broderick JP, Greenberg SM, Roquer J, Lindgren A, Slowik A, Schmidt R, Flaherty ML, Kleindorfer DO, Langefeld CD, Woo D, Rosand J; on behalf of the International Stroke Genetics Consortium. Stroke, 2012.

 

 

• TTC7B emerges as a novel risk factor for ischemic stroke through the convergence of several genome-wide approaches.

Krug, Tiago; Gabriel, João Paulo; Taipa, Ricardo; Fonseca, Maria B.; Domingues-Montanari, Sophie; Fernández Cadenas, Israel; Manso, Helena; Gouveia, Liliana; Sobral, João; Albergaria, Isabel; Gaspar, Gisela; Jiménez-Conde, Jordi; Rabionet, Raquel; Ferro, José; Montaner, Joan; Vicente, Astrid; Silva, Mário Rui; Matos, Ilda; Lopes, Gabriela; Oliveira, Sofia,. Journal of Cerebral Blood Flow & Metabolism,  2012.

 

 

• Role of the MMP9 gene in hemorrhagic transformations after t-PA treatment in stroke patients.

I. Fernández-Cadenas PhD; A. del Río-Espínola PhD; C. Carrera; S. Domingues-Montanari PhD; M. Mendióroz MD, PhD; P. Delgado MD, PhD; A. Rosell PhD; M. Ribó MD, PhD; D. Giralt; M. Quintana; M. Castellanos MD, PhD; V. Obach MD, PhD; S. Martínez MD, PhD; M.M. Freijo MD, J. Jiménez-Conde MD, PhD; J. Roquer MD, PhD; J. Martí- Fábregas MD, PhD; CA. Molina MD, PhD; J. Álvarez-Sabín MD, PhD; J. Montaner MD, PhD. Stroke 2012

 

 

• A Predictive Clinical-Genetic Model of t-PA Response in Acute Ischemic Stroke.

A. del Río-Espínola,* PhD,1 I. Fernández-Cadenas,* PhD,1 D. Giralt, BSc,1 A. Quiroga,2 M. Gutiérrez-Agulló, MSc,3 M. Quintana, BSc,4 P. Fernández-Álvarez, MSc,2 S. Domingues-Montanari, PhD,1 M. Mendióroz, MD, PhD,1 P. Delgado, MD, PhD,1 N. Turck, PhD,5 A. Ruíz, PhD,6 M. Ribó, MD, PhD,4 M. Castellanos, MD, PhD,7 V. Obach, MD, PhD,8 S. Martínez, MD, PhD,9 M.M. Freijo, MD,10 J. Jiménez-Conde, MD, PhD,11 E. Cuadrado-Godia, MD,11 J. Roquer, MD, PhD,11 P. Chacón, PhD,3 J. Martí-Fábregas, MD, PhD,9 J.C. Sánchez, PhD,5 GRECOS investigators,12 and J. Montaner,* MD PhD. Annals of Neurology, 2012.

 

 

• APOE genotype and extent of bleeding and outcome in lobar intracerebral haemorrhage: a genetic association study.

Biffi A, Anderson CD, Jagiella JM, Schmidt H, Kissela B, Hansen BM, Jimenez-Conde J, Pires CR, Ayres AM, Schwab K, Cortellini L, Pera J, Urbanik A, Romero JM, Rost NS, Goldstein JN, Viswanathan A, Pichler A, Enzinger C, Rabionet R, Norrving B, Tirschwell DL, Selim M, Brown DL, Silliman SL, Worrall BB, Meschia JF, Kidwell CS, Broderick JP, Greenberg SM, Roquer J, Lindgren A, Slowik A, Schmidt R, Woo D, Rosand J; on behalf of the International Stroke Genetics Consortium. Lancet Neurol. 2011 Aug;10(8):702-709.